Article
Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 1995
Meeker N D, Hickey W F, Korngold R, Hansen W K, Sudweeks J D, Wardell B B, Griffith J S, Teuscher C
Abstract excerpt
The existence of immunoregulatory genes conferring dominant resistance to autoimmunity is well documented. In an effort to better understand the nature and mechanisms of action of these genes, we utilized the murine model of autoimmune orchitis as a prototype. When the orchitis-resistant strain DBA/2J is crossed with the orchitis-susceptible strain BALB/cByJ, the F1 hybrid is completely resistant to the disease....
Topics
- Animals
- Autoimmune Diseases
- Bone Marrow
- Chimera
- Chromosome Mapping
- Genes, Dominant
- Genetic Linkage
- Genetic Predisposition to Disease
- Male
- Mice