Article
Interval mapping of quantitative trait loci controlling humoral immunity to exogenous antigens: evidence that non-MHC immune response genes may also influence susceptibility to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1996
Wu J, Longmate J A, Adamus G, Hargrave P A, Wakeland E K
Abstract excerpt
IgG Ab titers elicited to bovine rhodopsin in CFA differ 8- to 10-fold between H2s identical inbred strains A.SW/snJ (high responder) and SJL/snJ (low responder). This variation in IgG Ab titer resulted from a dramatic difference in the rise in Ab titer occurring during the maturation of the T-de...
Topics
- Animals
- Antigens, Heterophile
- Autoimmune Diseases
- Cattle
- Chromosome Mapping
- Disease Susceptibility
- Female
- Genes, MHC Class II
- Genetic Linkage
- Genetic Markers
- Genotype
- Immunoglobulin G
- Major Histocompatibility Complex
- Mice
- Mice, Inbred A
- Repetitive Sequences, Nucleic Acid
- Rhodopsin