Article
Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2002
Roper Randall J, Ma Runlin Z, Biggins Julia E, Butterfield Russell J, Michael Sandra D, Tung Kenneth S K, Doerge Rebecca W, Teuscher Cory
Abstract excerpt
Day 3 thymectomy (D3Tx) results in a loss of peripheral tolerance mediated by CD4(+)CD25(+) T cells and the development of autoimmune ovarian dysgenesis (AOD) in A/J and (C57BL/6J x A/J)F(1) (B6AF(1)) hybrids but not in C57BL/6J mice. Quantitative trait loci (QTL) linkage analysis using a B6AF(1) x C57BL/6J backcross population verified Aod1 and Aod2 that were previously mapped as qualitative traits....
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