The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor.

doi:10.1016/0922-4106(95)90036-5

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Article

The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor.

European journal of pharmacology - 15 Feb 1995

Jones P G, Curtis C A, Hulme E C

Abstract excerpt

Arg123 in the rat muscarinic M1 receptor is part of the highly conserved triad Asp-Arg-Tyr found at the junction of transmembrane helix 3 with the second intracellular loop. Mutation of Arg123 to Lys, Ala, Leu, Glu and Gln had no effect on levels of receptor expression in COS-7 cells, or on affinities for the antagonist N-methylscopolamine. Acetylcholine stimulation of the Lys123 receptor evoked the same maximum...

Topics

Acetylcholine
Amino Acid Sequence
Animals
Arginine
Carbachol
Cations, Divalent
Cell Line
Dose-Response Relationship, Drug
GTP-Binding Proteins
Hydrolysis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscarinic Agonists

Mutation

N-Methylscopolamine

Phosphatidylinositols

Rats

Receptors, Muscarinic

Scopolamine Derivatives

Source

Open in PubMed

Identifiers

PMID: 7774669
DOI: 10.1016/0922-4106(95)90036-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774669-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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