The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling.

doi:10.1124/mol.51.2.234

Back to search

Article

The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling.

Molecular pharmacology - 1 Feb 1997

Lu Z L, Curtis C A, Jones P G, Pavia J, Hulme E C

Abstract excerpt

An Asp-Arg-Tyr triad occurs in a majority of rhodopsin-like G protein-coupled receptors. The fully conserved Arg is critical for G protein activation, but the function of the flanking residues is not well understood. We expressed in COS-7 cells m1 muscarinic receptors that were mutated at Asp122...

Topics

Acetylcholine
Animals
Arginine
Aspartic Acid
Cells, Cultured
Dose-Response Relationship, Drug
Mutation
Receptors, Muscarinic
Signal Transduction
Tyrosine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.