Article
Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2010
Strandberg Linn S, Ambrosi Aurelie, Jagodic Maja, Dzikaite Vijole, Janson Peter, Khademi Mohsen, Salomonsson Stina, Ottosson Lars, Klauninger Robert, Adén Ulrika, Sonesson Sven-Erik, Sunnerhagen Maria, de Graaf Katrien L, Kuchroo Vijay K, Achour Adnane, Winqvist Ola, Olsson Tomas, Wahren-Herlenius Marie
Abstract excerpt
Congenital heart block develops in fetuses of anti-Ro52 Ab-positive women. A recurrence rate of 20%, despite the persistence of maternal autoantibodies, indicates that there are additional, yet unidentified, factors critical for development of congenital heart block. In this study, we demonstrate that besides the maternal MHC controlling Ab specificity, fetal MHC-encoded genes influence fetal susceptibility to...
Topics
- Amino Acid Sequence
- Animals
- Antibody Specificity
- Atrioventricular Block
- Autoantibodies
- Cell Line
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease