Article

Biological and Clinical Applications of Dimethyl Sulfoxide: Evidence and Safety Considerations

2026-07-15

Abstract excerpt

Dimethyl sulfoxide (DMSO) is a polar aprotic solvent commonly used as a cryoprotectant, permeability enhancer, and laboratory vehicle. Its biological effects vary across experimental and clinical settings and should not be interpreted as evidence of therapeutic benefit. This narrative review evaluates DMSO in membrane biophysics, inflammatory and cellular stress responses, interstitial cystitis/bladder pain syndro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4cce497-e860-56c5-820c-2479a950bcc6
DOI: 10.20944/preprints202607.1040.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biological and Clinical Applications of Dimethyl Sulfoxide: Evidence and Safety ConsiderationsDOI 10.20944/preprints202607.1040.v1Read

DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitroSemantic proximity Read

The Role of Dimethyl Sulfoxide (DMSO) in Gene Expression Modulation and Glycosaminoglycan Metabolism in Lysosomal Storage Disorders on an Example of MucopolysaccharidosisSemantic proximity Read

Dimethyl Sulfoxide Perturbs Cell Cycle Progression and Spindle Organization in Porcine Meiotic OocytesSemantic proximity Read

Real-time studies of plasma membrane damage trigger cell apoptosis from sulfhydryl nanoparticles to support safety assessment of nanoscale materialsSemantic proximity Read

Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological SystemsSemantic proximity Read

Cell Spinpods: A Simple Inexpensive Device to Determine Suspension Culture and Toxicity Effects on Renal Proximal Tubular CellsSemantic proximity Read

DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: Low temperature characterization and protocol developmentSemantic proximity Read

Cinnamon-mediated nano emulsion and its cryogenic activity on ROS-affected human sperm—A short studySemantic proximity Read

Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS).Semantic proximity Read

Addition of DMSO to T cell cultures skews differentiation towards a memory phenotypeSemantic proximity Read

Interventions with Potential to Mitigate Injection Site Reactions Following Subcutaneous Elamipretide Administration: A Phase 1, Crossover StudySemantic proximity Read

A Concept on The Development of The DRDE Series of Compounds for Skin Diseases Using In-Silico ADME And Drug-Likeness AnalysisSemantic proximity Read