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Article

The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya.

Chemistry & biology - 1 Apr 2003

Núñez Luz Elena, Méndez Carmen, Braña Alfredo F, Blanco Gloria, Salas José A

Abstract excerpt

beta-lactam ring formation in carbapenem and clavam biosynthesis proceeds through an alternative mechanism to the biosynthetic pathway of classic beta-lactam antibiotics. This involves the participation of a beta-lactam synthetase. Using available information from beta-lactam synthetases, we generated a probe for the isolation of the thienamycin cluster from Streptomyces cattleya. Genes homologous to carbapenem...

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PMID: 12725858
DOI: 10.1016/s1074-5521(03)00069-3

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