Article
Microbial isopenicillin N synthase genes: structure, function, diversity and evolution.
Trends in biotechnology - 1 Apr 1990
Cohen G, Shiffman D, Mevarech M, Aharonowitz Y
Abstract excerpt
Clinically and economically, penicillins and cephalosporins are the most important class of the beta-lactam antibiotics. They are produced by a wide variety of microorganisms including numerous species of Streptomyces, some unicellular bacteria and several filamentous fungi. A key step common to their biosynthetic pathways is the conversion of a linear, cysteine-containing tripeptide to a bicyclic beta-lactam...
Topics
- Amino Acid Sequence
- Biological Evolution
- Genetic Variation
- Molecular Sequence Data
- Oxidoreductases
- Streptomyces
- Structure-Activity Relationship