Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.

doi:10.1099/13500872-140-12-3367

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Article

Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.

Microbiology (Reading, England) - 1 Dec 1994

Yu H, Serpe E, Romero J, Coque J J, Maeda K, Oelgeschläger M, Hintermann G, Liras P, Martín J F, Demain A L

Abstract excerpt

Streptomyces clavuligerus produces the beta-lactam antibiotics penicillin N, O-carbamoyldeacetylcephalosporin C and cephamycin C. We characterized a wild-type DNA region which restores antibiotic formation to a mutant strain named NP1, previously shown to exhibit depressed activities for two early enzymes of cephalosporin synthesis, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS) and...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Base Sequence
Cephalosporins
DNA, Bacterial
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genetic Complementation Test
L-Lysine 6-Transaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oxidoreductases

Peptide Synthases

Promoter Regions, Genetic

Sequence Deletion

Streptomyces

Transaminases

Source

Open in PubMed

Identifiers

PMID: 7881554
DOI: 10.1099/13500872-140-12-3367

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7881554-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.PMID 7881554Read ↗

Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

Genes for beta-lactam antibiotic biosynthesis.Semantic proximity Read ↗

Genetic and biochemical analysis of the cysteinyl residues of isopenicillin N synthase from Streptomyces clavuligerus.Semantic proximity Read ↗

Microbial isopenicillin N synthase genes: structure, function, diversity and evolution.Semantic proximity Read ↗

An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.Semantic proximity Read ↗

Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

Mutation of N304 to leucine in Streptomyces clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion.Semantic proximity Read ↗

The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus.Semantic proximity Read ↗

Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene The GenBank accession number for the 12162 bp sequence reported in this paper is AY034175.Semantic proximity Read ↗

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.Semantic proximity Read ↗

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