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Article

Use of mutagens to increase rate of immunoglobulin isotype switching of hybridoma cells.

Hybridoma - 1 Feb 1995

Paizi M, Zivion D, Spira G

Abstract excerpt

Isotype switching of hybridoma clones may be essential when the class of the antibody produced does not suit the task for which it was generated. In those instances immunoglobulin (Ig) switch variants can be isolated in vitro but the success of isolating these rare variants primarily depends on the frequency of switching of each individual hybridoma. Variations in the frequency are noted not only between...

Topics

Aminacrine
Animals
Antibodies, Monoclonal
Genetic Variation
Hybridomas
Immunoglobulin Class Switching
Mice
Mutagenesis
Mutagens
Nitrogen Mustard Compounds

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7768537
DOI: 10.1089/hyb.1995.14.85

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7768537-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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