Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of mutagens to increase rate of immunoglobulin isotype switching of hybridoma cells.

Hybridoma - 1 Feb 1995

Paizi M, Zivion D, Spira G

Abstract excerpt

Isotype switching of hybridoma clones may be essential when the class of the antibody produced does not suit the task for which it was generated. In those instances immunoglobulin (Ig) switch variants can be isolated in vitro but the success of isolating these rare variants primarily depends on the frequency of switching of each individual hybridoma. Variations in the frequency are noted not only between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Genetic Variation
Share to Hybridomas

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Class Switching

Share to Mutagenesis

Share to Mutagens

Source

Identifiers

PMID: 7768537
DOI: 10.1089/hyb.1995.14.85

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of mutagens to increase rate of immunoglobulin isotype switching of hybridoma cells.PMID 7768537Read ↗

Identification of rare immunoglobulin switch variants using the ELISA spot assay.Semantic proximity Read ↗

Simultaneous expression of kappa and lambda light chains in a murine IgG3 anti-Cryptococcus neoformans hybridoma cell line.Semantic proximity Read ↗

Molecular comparison of cultured hybridoma cells that switch isotypes at high and low rates.Semantic proximity Read ↗

The use of chemiluminescence and the ELISA spot assay to identify and enumerate rare immunoglobulin switch variants.Semantic proximity Read ↗

Generation of Murine Monoclonal Antibodies by Hybridoma TechnologySemantic proximity Read ↗

Generation of Murine Monoclonal Antibodies by Hybridoma TechnologySemantic proximity Read ↗

Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.Semantic proximity Read ↗

Isolation by fluorescence-activated cell sorting of cells of a human lymphoblastoid cell strain containing mutations in the lambda immunoglobulin gene.Semantic proximity Read ↗

Production of mouse monoclonal antibodies against human HLA-A3 for use in microlymphocytotoxicity technique.Semantic proximity Read ↗

In vitro activation of a nonproductive immunoglobulin allele by a single base pair insertion.Semantic proximity Read ↗

Instability of chimaeric antibody secretion by anti-carcinoembryonic antigen producing hybridoma cells after gene targeting.Semantic proximity Read ↗

Detection of gene targeting by co-conversion of a single nucleotide change during replacement recombination at the immunoglobulin mu heavy chain locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.