The use of chemiluminescence and the ELISA spot assay to identify and enumerate rare immunoglobulin switch variants.

doi:10.1016/0022-1759(93)90352-8

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Article

The use of chemiluminescence and the ELISA spot assay to identify and enumerate rare immunoglobulin switch variants.

Journal of immunological methods - 15 Oct 1993

Spira G, Gregor P D, Scharff M D

Abstract excerpt

The use of chemiluminescence and the ELISA spot assay for identifying rare immunoglobulin switch variants is described. The technique utilizes nitrocellulose membranes and allows rapid screening of a large number of cells. The number of spots can be recorded either manually or automatically by us...

Topics

Animals
Enzyme-Linked Immunosorbent Assay
Genetic Variation
Hybridomas
Immunoglobulin G
Immunoglobulin Isotypes
Immunoglobulin M
Immunoglobulin Switch Region
Luminescent Measurements
Mice
Mice, Inbred A
Mice, Inbred BALB C
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 8228276
DOI: 10.1016/0022-1759(93)90352-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8228276-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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