Article
The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2010
Fritz Jason M, Dwyer-Nield Lori D, Russell Bridgette M, Malkinson Alvin M
Abstract excerpt
BACKGROUND: Human lung cancer patients exhibit different KRAS mutations depending on smoking status. In a mouse model of human cancer, A/J and BALB/cBy mice treated with the tobacco carcinogen, 3-methylcholanthrene (MCA), followed by butylated hydroxytoluene (BHT)-elicited chronic inflammation develop a high multiplicity of lung tumors. METHODS: DNA was isolated from MCA-induced lung tumors in A/J and BALB/cByJ...
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