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Article

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.

Genesis (New York, N.Y. : 2000) - 1 Aug 2003

Wu Lin, Gu Jun, Weng Yan, Kluetzman Kerri, Swiatek Pam, Behr Melissa, Zhang Qing-Yu, Zhuo Xiaoliang, Xie Qiang, Ding Xinxin

Abstract excerpt

NADPH-cytochrome P450 reductase (CPR or POR) is the obligatory electron donor for all microsomal cytochrome P450 (CYP or P450)-catalyzed monooxygenase reactions. Disruption of the mouse Cpr gene has been reported to cause prenatal developmental defects and embryonic lethality. In this study, we generated a mouse model with a floxed Cpr allele (termed Cpr(lox)). Homozygous Cpr(lox) mice are fertile and without any...

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PMID: 12929087
DOI: 10.1002/gene.10214

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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