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Article

Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.

Physiological reviews - 1 Jan 2009

Turgeon Benjamin, Meloche Sylvain

Abstract excerpt

The mouse represents the model of choice to study the biological function of mammalian genes through mutation of its genome. However, the biggest challenge of mouse geneticists remains the phenotypic analysis of mouse mutants. A survey of mouse mutant databases reveals a surprisingly high number of gene mutations leading to neonatal death. These genetically modified mouse mutants have been instrumental in...

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PMID: 19126753
DOI: 10.1152/physrev.00040.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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