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Article

Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendages.

Journal of leukocyte biology - 1 Jun 2003

Ratner Stuart, Piechocki Marie P, Galy Anne

Abstract excerpt

Lymphocytes polarize for motility by developing a broad anterior, where lamellipodia arise, and a simple stalk-like posterior appendage, the uropod. Through time-lapse analysis of normal and leukemic human T cells, it was found that this polarized form is maintained by a mechanism that excludes lamellipodia from the uropod. Lamellipodia regularly traveled rearward to encroach upon the uropod but disassembled...

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Source

Identifiers

PMID: 12773516
DOI: 10.1189/jlb.1001894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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