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Article

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner.

Molecular and cellular biology - 1 Jun 1995

Michaud N R, Fabian J R, Mathes K D, Morrison D K

Abstract excerpt

Recent reports have demonstrated the in vivo association of Raf-1 with members of the 14-3-3 protein family. To address the significance of the Raf-1-14-3-3 interaction, we investigated the enzymatic activity and biological function of Raf-1 in the presence and absence of associated 14-3-3. The interaction between these two molecules was disrupted in vivo and in vitro with a combination of molecular and...

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Identifiers

PMID: 7760835
DOI: 10.1128/MCB.15.6.3390
PMCID: PMC230573

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