Article
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Molecular and cellular biology - 1 Oct 2010
Molzan Manuela, Schumacher Benjamin, Ottmann Corinna, Baljuls Angela, Polzien Lisa, Weyand Michael, Thiel Philipp, Rose Rolf, Rose Micheline, Kuhenne Philipp, Kaiser Markus, Rapp Ulf R, Kuhlmann Jürgen, Ottmann Christian
Abstract excerpt
The Ras-RAF-mitogen-activated protein kinase (Ras-RAF-MAPK) pathway is overactive in many cancers and in some developmental disorders. In one of those disorders, namely, Noonan syndrome, nine activating C-RAF mutations cluster around Ser(259), a regulatory site for inhibition by 14-3-3 proteins. We show that these mutations impair binding of 14-3-3 proteins to C-RAF and alter its subcellular localization by...
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