A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.

doi:10.1038/27938

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Article

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.

Nature - 2 Jul 1998

Tzivion G, Luo Z, Avruch J

Abstract excerpt

cRaf-1 is a mitogen-activated protein kinase that is the main effector recruited by GTP-bound Ras in order to activate the MAP kinase pathway. Inactive Raf is found in the cytosol in a complex with Hsp90, Hsp50 (Cdc37) and the 14-3-3 proteins. GTP-bound Ras binds Raf and is necessary but not suff...

Topics

14-3-3 Proteins
Animals
COS Cells
Dimerization
Enzyme Activation
Mutation
Phosphopeptides
Phosphorylation
Protein Kinase C
Proteins
Proto-Oncogene Proteins c-myc
Proto-Oncogene Proteins c-raf
Recombinant Proteins
Serine
Transfection
Tyrosine 3-Monooxygenase

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