Article
The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival.
Annals of neurology - 1 May 1995
van Duijn C M, de Knijff P, Wehnert A, De Voecht J, Bronzova J B, Havekes L M, Hofman A, Van Broeckhoven C
Abstract excerpt
It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE*2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE*2 allele in the pathogenesis of EOAD in a Dutch population-based study of 175 probable EOAD patients with onset age at or before 65 years and 532 age-matched controls. In our...
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