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Article

Development and characterization of a conditionally immortalized human fetal osteoblastic cell line.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 1995

Harris S A, Enger R J, Riggs B L, Spelsberg T C

Abstract excerpt

We report the establishment of a human fetal osteoblast cell line derived from biopsies obtained from a spontaneous miscarriage. Primary cultures isolated from fetal tissue were transfected with a gene coding for a temperature-sensitive mutant (tsA58) of SV40 large T antigen along with a gene coding for neomycin (G418) resistance. Individual neomycin resistant colonies were screened for alkaline phosphatase...

Topics

Alkaline Phosphatase
Antigens, Viral, Tumor
Calcification, Physiologic
Calcitriol
Cell Adhesion
Cell Differentiation
Cell Division
Cell Line
Cyclic AMP
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Fetus

Gene Expression Regulation, Developmental

Humans

Karyotyping

Mutation

Osteoblasts

Osteocalcin

Source

Identifiers

PMID: 7754797
DOI: 10.1002/jbmr.5650100203

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7754797-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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