Article
Immortalization of human marrow stromal cells by retroviral transduction with a temperature sensitive oncogene: identification of bipotential precursor cells capable of directed differentiation to either an osteoblast or adipocyte phenotype.
Bone - 1 Jan 1998
Houghton A, Oyajobi B O, Foster G A, Russell R G, Stringer B M
Abstract excerpt
The etiology of osteoporosis is multifactorial, but there is evidence from both animal and human studies that the volume of marrow adipose tissue increases when bone volume is reduced in osteoporosis. The cell-related mechanism that may account for this inverse relationship between the volume of...
Topics
- Adipocytes
- Aged
- Alkaline Phosphatase
- Antigens, Polyomavirus Transforming
- Bone Marrow Cells
- Calcitriol
- Cell Culture Techniques
- Cell Differentiation
- Cell Transformation, Viral
- Cyclic AMP
- DNA Primers
- Dexamethasone
- Dinoprostone