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Article

Location in the large bowel influences the APC mutations observed in FAP adenomas.

Familial cancer - 1 Sept 2010

Will O C, Leedham S J, Elia G, Phillips R K S, Clark S K, Tomlinson I P M

Abstract excerpt

The right colon differs from the left, in embryological origin, luminal environment, and function. In both sporadic colorectal cancer and Familial Adenomatous Polyposis (FAP), polyp density and cancer susceptibility vary markedly by colonic site. Adenomas in FAP have a different mutational spectrum in small intestine versus colon. This study aimed to investigate whether colonic location also influences the APC...

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Source

Identifiers

PMID: 20229069
DOI: 10.1007/s10689-010-9332-y

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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