Article
Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells.
Lancet (London, England) - 27 May 1995
Almond N, Kent K, Cranage M, Rud E, Clarke B, Stott E J
Abstract excerpt
A vaccine against AIDS will probably have to protect against challenge both by viable virus-infected cells and by cell-free virus. Eight cynomolgus macaques infected with attenuated simian immunodeficiency virus (SIV) were challenged (four each) with cell-free and cell-associated SIV. All were protected, whereas eight controls were all infected after challenge. These findings show that live-attenuated vaccine can...
Topics
- AIDS Vaccines
- Animals
- Antibodies, Viral
- Disease Models, Animal
- Genes, nef
- Humans
- Macaca fascicularis
- Mutation
- SAIDS Vaccines
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus