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Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIV<sub>mac251</sub>at Challenge Exposure

17 Jan 2013

Abstract excerpt

We used the simian immunodeficiency virus mac251 (SIV(mac251)) macaque model to study the effect of the dose of mucosal exposure on vaccine efficacy. We immunized macaques with a DNA prime followed by SIV gp120 protein immunization with ALVAC-SIV and gp120 in alum, and we challenged them with SIV(mac251) at either a single high dose or at two repeated low-dose exposures to a 10-fold-lower dose. Infection was...

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PMID: 23325681
DOI: 10.1128/jvi.02863-12

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