Article
Live attenuated lentivirus infection elicits polyfunctional simian immunodeficiency virus Gag-specific CD8+ T cells with reduced apoptotic susceptibility in rhesus macaques that control virus replication after challenge with pathogenic SIVmac239.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007
Genescà Meritxell, Rourke Tracy, Li Jun, Bost Kristen, Chohan Barinderpaul, McChesney Michael B, Miller Christopher J
Abstract excerpt
HIV-specific CD8+ T cells that secrete multiple cytokines in response to Ag stimulation are associated with the control of virus replication during chronic HIV infection. To determine whether the presence of polyfunctional CD8+ T cell responses distinguishes protected and unprotected monkeys in a live attenuated lentivirus model, SIV Gag peptide-specific CD8+ T cell responses of simian HIV (SHIV) 89.6-vaccinated,...
Topics
- Animals
- Apoptosis
- CD8-Positive T-Lymphocytes
- Disease Susceptibility
- Gene Products, gag
- Immunologic Memory
- Lentivirus Infections
- Macaca mulatta
- Male
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- RNA Viruses