Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

doi:10.1038/305600a0

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Article

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.

Nature - 1 Jan 2000

Montell C, Fisher E F, Caruthers M H, Berk A J

Abstract excerpt

A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not require...

Topics

Adenoviruses, Human
Base Sequence
DNA
Genes, Viral
HeLa Cells
Humans
Mutation
Poly A
RNA
RNA, Messenger
RNA, Viral
Transcription, Genetic

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