Article
The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure.
Nucleic acids research - 15 Jan 1999
Klasens B I, Thiesen M, Virtanen A, Berkhout B
Abstract excerpt
The 5' and 3' ends of HIV-1 transcripts are identical in sequence. This repeat region (R) folds a stem-loop structure that is termed the poly(A) hairpin because it contains polyadenylation or poly(A) signals: the AAUAAA hexamer motif, the cleavage site and part of the GU-rich downstream element....
Topics
- Enhancer Elements, Genetic
- Gene Expression Regulation, Viral
- HIV-1
- Models, Genetic
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- RNA, Viral
- RNA-Binding Proteins
- mRNA Cleavage and Polyadenylation Factors