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Article

The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure.

Nucleic acids research - 15 Jan 1999

Klasens B I, Thiesen M, Virtanen A, Berkhout B

Abstract excerpt

The 5' and 3' ends of HIV-1 transcripts are identical in sequence. This repeat region (R) folds a stem-loop structure that is termed the poly(A) hairpin because it contains polyadenylation or poly(A) signals: the AAUAAA hexamer motif, the cleavage site and part of the GU-rich downstream element. Obviously, HIV-1 gene expression necessitates differential regulation of the two poly(A) sites. Previous transfection...

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Identifiers

PMID: 9862964
DOI: 10.1093/nar/27.2.446
PMCID: PMC148199

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Source receipt: pubmed, retrieved 7 Sept 2026.

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