Article
Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1beta convertase) alters proteolytic activity and ablates zymogen processing.
Infection and immunity - 1 Jun 1996
Musser J M, Stockbauer K, Kapur V, Rudgers G W
Abstract excerpt
Virtually all strains of the human pathogenic bacterium Streptococcus pyogenes express a highly conserved extracellular cysteine protease. The protein is made as an inactive zymogen of 40,000 Da and undergoes autocatalytic truncation to result in a 28,000-Da active protease. Numerous independent...
Topics
- Animals
- Base Sequence
- Caspase 1
- Cattle
- Cysteine
- Cysteine Endopeptidases
- Enzyme Precursors
- Escherichia coli
- Humans
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- Streptococcus pyogenes