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Article

The tempo and mode of SIV quasispecies development in vivo calls for massive viral replication and clearance.

Virology - 20 Apr 1995

Pelletier E, Saurin W, Cheynier R, Letvin N L, Wain-Hobson S

Abstract excerpt

Simian immunodeficiency virus (SIV) quasispecies development was followed in four monkeys (Macacca fascicularis) infected by intramuscular inoculation of phage lambda-SIVmac239 DNA. Rooted phylogenetic trees were reconstructed and used to interpret the data. The rate of fixation of base substitutions varied within and between animals reaching 3.3 x 10(-2) per site per year. These data suggest that the tempo of...

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PMID: 7747436
DOI: 10.1006/viro.1995.1195

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