Article
Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host.
Retrovirology - 20 Mar 2006
Demma L J, Vanderford T H, Logsdon J M, Feinberg M B, Staprans S I
Abstract excerpt
BACKGROUND: The ability of emerging pathogens to infect new species is likely related to the diversity of pathogen variants present in existing reservoirs and their degree of genomic plasticity, which determines their ability to adapt to new environments. Certain simian immunodeficiency viruses (SIVcpz, SIVsm) have demonstrated tremendous success in infecting new species, including humans, resulting in the HIV-1...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Viral
- Evolution, Molecular
- Genetic Variation
- HIV-1
- Humans
- Phylogeny
- Primates
- Reverse Transcriptase Polymerase Chain Reaction
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Viral Envelope Proteins
- Zoonoses
