Article
SIV Evolutionary Dynamics in Cynomolgus Macaques during SIV-Mycobacterium tuberculosis Co-Infection.
Viruses - 29 Dec 2021
Tisthammer Kaho H, Kline Christopher, Rutledge Tara, Diedrich Collin R, Ita Sergio, Lin Philana Ling, Ambrose Zandrea, Pennings Pleuni S
Abstract excerpt
Co-infection with Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) is a worldwide public health concern, leading to worse clinical outcomes caused by both pathogens. We used a non-human primate model of simian immunodeficiency virus (SIV)-Mtb co-infection, in which latent Mtb infection was established prior to SIVmac251 infection. The evolutionary dynamics of SIV env was evaluated from...
Topics
- Amino Acid Substitution
- Animals
- Antibodies, Neutralizing
- Antibodies, Viral
- Biodiversity
- CD8-Positive T-Lymphocytes
- Coinfection
- Evolution, Molecular
- HIV Infections
- Humans
- Macaca fascicularis
- Mutation
- Mycobacterium tuberculosis