Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease.

doi:10.1002/ana.410380120

Back to search

Article

Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease.

Annals of neurology - 1 Jul 1995

Sorbi S, Nacmias B, Forleo P, Piacentini S, Latorraca S, Amaducci L

Abstract excerpt

We found a new familial Alzheimer's disease kindred in which the disease cosegregates with the APP717Val-->Ile mutation and in which all of the three most common apolipoprotein E (ApoE) alleles are represented. We studied the relationship between ApoE genotype and the clinical expression of the d...

Topics

Adult
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoproteins E
Base Sequence
Epistasis, Genetic
Female
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Pedigree

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.