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Article

Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease.

Annals of neurology - 1 Jul 1995

Sorbi S, Nacmias B, Forleo P, Piacentini S, Latorraca S, Amaducci L

Abstract excerpt

We found a new familial Alzheimer's disease kindred in which the disease cosegregates with the APP717Val-->Ile mutation and in which all of the three most common apolipoprotein E (ApoE) alleles are represented. We studied the relationship between ApoE genotype and the clinical expression of the disease and found that in this amyloid precursor protein-mutated family, ApoE genotype influences the age at onset of...

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Identifiers

PMID: 7611715
DOI: 10.1002/ana.410380120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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