Article
T-antigen-dependent transcriptional initiation and its role in the regulation of human neurotropic JC virus late gene expression.
The Journal of general virology - 1 Sept 1998
Raj G V, Gallia G L, Chang C F, Khalili K
Abstract excerpt
The multifunctional protein of papovaviruses, T-antigen, regulates the virus lytic cycle partly by exerting transcriptional control over viral and cellular gene expression. In this study, the ability of the T-antigen of human neurotropic JC virus (JCV) to enhance expression from the virus late promoter has been further examined. By deletion analysis, a T-antigen-responsive region was mapped within the JCV 98 bp...
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