Article
T-antigen-dependent transcriptional initiation and its role in the regulation of human neurotropic JC virus late gene expression.
The Journal of general virology - 1 Sept 1998
Raj G V, Gallia G L, Chang C F, Khalili K
Abstract excerpt
The multifunctional protein of papovaviruses, T-antigen, regulates the virus lytic cycle partly by exerting transcriptional control over viral and cellular gene expression. In this study, the ability of the T-antigen of human neurotropic JC virus (JCV) to enhance expression from the virus late pr...
Topics
- Antigens, Viral, Tumor
- Base Sequence
- Binding Sites
- Cell Line
- DNA, Viral
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Genes, Viral
- HeLa Cells
- Humans
- JC Virus
- Mutation
- Oligodeoxyribonucleotides
- Promoter Regions, Genetic
- Sequence Deletion
- Transcriptional Activation
- Transfection