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Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx

1 Jun 1995

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vpr and Vpx proteins are packaged into virions through virus type-specific interactions with the Gag polyprotein precursor. To examine whether HIV-1 Vpr (Vpr1) and HIV-2 Vpx (Vpx2) could be used to target foreign proteins to the HIV particle, their open reading frames were fused in frame with genes encoding the bacterial staphylococcal nuclease (SN), an...

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Identifiers

PMID: 7745685
DOI: 10.1128/jvi.69.6.3389-3398.1995

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