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Article

Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles.

Journal of virology - 1 Jun 1996

Wu X, Liu H, Xiao H, Conway J A, Kappes J C

Abstract excerpt

The human immunodeficiency virus type I (HIV-1) Vpr and HIV-2 Vpx proteins package into virions through interactions with their cognate Gag polyprotein precursor. The targeting properties of Vpr and Vpx have been exploited to incorporate foreign proteins into virions by expression as heterologous...

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Identifiers

PMID: 8648668
DOI: 10.1128/JVI.70.6.3378-3384.1996
PMCID: PMC190209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8648668-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles.PMID 8648668Read ↗

Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and VpxSemantic proximity Read ↗

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particlesSemantic proximity Read ↗

A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particlesSemantic proximity Read ↗

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Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeficiency Virus VpxSemantic proximity Read ↗

Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins.Semantic proximity Read ↗

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Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral InfectivitySemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Gag Polyprotein Multimerization Requires the Nucleocapsid Domain and RNA and Is Promoted by the Capsid-Dimer Interface and the Basic Region of Matrix ProteinSemantic proximity Read ↗

Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor.Semantic proximity Read ↗

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