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Article

Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity.

Molecular microbiology - 1 Mar 2002

Ye Dan, Blanke Steven R

Abstract excerpt

The Helicobacter pylori vacuolating cytotoxin (VacA) induces degenerative vacuolation of sensitive mammalian cell lines. Although evidence is accumulating that VacA enters cells and functions from an intracellular site of action, the biochemical mechanism by which VacA mediates cellular vacuolation has not been established. In this study, we used functional complementation and biochemical approaches to probe the...

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Identifiers

PMID: 11918810
DOI: 10.1046/j.1365-2958.2002.02818.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity.PMID 11918810Read ↗

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