Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors.

Journal of cell science - 1 Feb 2005

Depuydt Bart, van Loo Geert, Vandenabeele Peter, Declercq Wim

Abstract excerpt

Previously we reported that both human TNFR1 and TNFR2 mediate TNF-induced apoptosis in the transfected rat/mouse T cell hybridoma PC60. We show here that TNFR2-mediated apoptosis in PVC60 cells can be blocked by the broad-spectrum caspase inhibitor zVAD-fmk, the caspase-8 inhibitor zIETD-fmk and by CrmA, a viral inhibitor of caspase-1 and caspase-8. This suggests an involvement of caspase-8 in TNFR2-mediated...

Topics

Adaptor Proteins, Signal Transducing
Animals
Apoptosis
Caspase 8
Caspase Inhibitors
Caspases
Cell Survival
Cycloheximide
Cysteine Proteinase Inhibitors
Fas-Associated Death Domain Protein
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hybridomas

Mice

Mutation

Rats

Receptors, Tumor Necrosis Factor, Type I

Receptors, Tumor Necrosis Factor, Type II

T-Lymphocytes

Source

Identifiers

PMID: 15657078
DOI: 10.1242/jcs.01640

Genes

FADD
TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors.PMID 15657078Read ↗

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.Semantic proximity Read ↗

The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells.Semantic proximity Read ↗

CD2-induced apoptosis in activated human peripheral T cells: a Fas-independent pathway that requires early protein tyrosine phosphorylation.Semantic proximity Read ↗

Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2: presence of Bcl-2 dependent and independent pathways.Semantic proximity Read ↗

Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene.Semantic proximity Read ↗

NF kappa B controls the balance between Fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20.Semantic proximity Read ↗

Defective death receptor signaling as a cause of tumor immune escape.Semantic proximity Read ↗

Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.Semantic proximity Read ↗

Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.Semantic proximity Read ↗

APO2 ligand: a novel lethal weapon against malignant glioma?Semantic proximity Read ↗

TRAIL/Apo-2-ligand-induced apoptosis in human T cellsSemantic proximity Read ↗

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced ApoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.