Article
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.
The EMBO journal - 1 Jun 1999
Grell M, Zimmermann G, Gottfried E, Chen C M, Grünwald U, Huang D C, Wu Lee Y H, Dürkop H, Engelmann H, Scheurich P, Wajant H, Strasser A
Abstract excerpt
Several members of the tumour necrosis factor receptor (TNF-R) superfamily can induce cell death. For TNF-R1, Fas/APO-1, DR3, DR6, TRAIL-R1 and TRAIL-R2, a conserved 'death domain' in the intracellular region couples these receptors to activation of caspases. However, it is not yet known how TNF receptor family members lacking a death domain, such as TNF-R2, CD40, LT-betaR, CD27 or CD30, execute their...
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