Comparative bioavailability of two oral metamizole formulations. Influence of the acetylation phenotype.

Article

Comparative bioavailability of two oral metamizole formulations. Influence of the acetylation phenotype.

Arzneimittel-Forschung - 1 Mar 1995

Bacracheva N, Drenska A, Gorantcheva J, Tyutyulkova N, Vlahov V

Abstract excerpt

The bioavailability of the four metabolites of metamizole (CAS 68-89-3), 4-methyl-amino-antipyrine (4-MAA), 4-formyl-amino-antipyrine (4-FAA), 4-amino-antipyrine (4-AA) and 4-acetyl-amino-antipyrine (4-AcAA) was compared after oral administration of a test (Analgin) and a reference formulation, b...

Topics

Acetylation
Adult
Antipyrine
Biological Availability
Bulgaria
Caffeine
Cross-Over Studies
Dipyrone
Female
Humans
Male
Phenotype
Therapeutic Equivalency

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