Potential influence of body weight on the clearance of polymorphically acetylated drugs.

doi:10.1002/j.1552-4604.1982.tb02673.x

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Article

Potential influence of body weight on the clearance of polymorphically acetylated drugs.

Journal of clinical pharmacology - 1 Jan 2000

Chapron D J, Kramer P A, Mercik S A

Abstract excerpt

The acetylation clearance of sulfamethazine was found to be significantly dependent upon body weight in both intermediate and rapid acetylators. The correlation between acetylation clearance and body weight was stronger in the rapid acetylator. It is recommended that weight-corrected acetylation...

Topics

Acetylation
Body Weight
Humans
Kinetics
Models, Biological
Pharmaceutical Preparations
Phenotype
Sulfamethazine

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