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Article

Potential influence of body weight on the clearance of polymorphically acetylated drugs.

Journal of clinical pharmacology - 1 Jan 2000

Chapron D J, Kramer P A, Mercik S A

Abstract excerpt

The acetylation clearance of sulfamethazine was found to be significantly dependent upon body weight in both intermediate and rapid acetylators. The correlation between acetylation clearance and body weight was stronger in the rapid acetylator. It is recommended that weight-corrected acetylation clearance values be used when constructing distribution histograms for phenotyping purposes. Within a phenotypic mode,...

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Identifiers

PMID: 7107974
DOI: 10.1002/j.1552-4604.1982.tb02673.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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