Article
In vitro stability of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma.
Thrombosis and haemostasis - 1 Dec 1994
Rijken D C, Groeneveld E, Barrett-Bergshoeff M M
Abstract excerpt
BM 06.022 is a non-glycosylated mutant of human tissue-type plasminogen activator (t-PA) comprising only the kringle-2 and proteinase domains. The in vivo half-life of BM 06.022 antigen is 4- to 5-fold longer than that of t-PA antigen. The in vitro half-life of the activity of BM 06.022 at therapeutic concentrations in plasma is shorter than that of t-PA. In this study the inactivation of BM 06.022 in plasma was...
Topics
- Drug Stability
- Fibrinolytic Agents
- Half-Life
- Humans
- Mutation
- Protease Inhibitors
- Recombinant Proteins
- Tissue Plasminogen Activator