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Article

Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2006

Gurewich V, Pannell R, Simmons-Byrd A, Sarmientos P, Liu J-N, Badylak S F

Abstract excerpt

BACKGROUND: A single site mutant (M5) of prourokinase (proUK) was developed to make proUK less vulnerable to spontaneous activation in plasma. This was a problem that seriously compromised proUK in clinical trials, as it precluded proUK-mediated fibrinolysis at therapeutic concentrations. METHODS AND RESULTS: After completing dose-finding studies, 12 anesthetized dogs with femoral artery thrombosis were given...

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Identifiers

PMID: 16839354
DOI: 10.1111/j.1538-7836.2006.01993.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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