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Article

A Novel Fibrinolysis Resistance Capacity Assay can Detect Fibrinolytic Phenotypes in Trauma Patients.

Thrombosis and haemostasis - 1 Dec 2025

Barrett Christopher D, Suzuki Yuko, Moore Ernest E, Moore Hunter B, Maginot Elizabeth R, White Collin M, Siddiqui Halima, Gawargi Flobater I, Chandler James G, Sauaia Angela, Urano Tetsumei

Abstract excerpt

To evaluate residual fibrinolysis resistance activity (FRA) in plasma, a detergent-modified plasma clot lysis assay time (dPCLT) was established in which α2-antiplasmin (A2AP) and plasminogen activator inhibitor type 1 (PAI-1) are inactivated without impacting protease activity. We applied this novel assay to severely injured trauma patients' plasma.Tissue-type plasminogen activator (tPA)-induced plasma clot...

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Identifiers

PMID: 39837554
DOI: 10.1055/a-2508-3424
PMCID: PMC13433134

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