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Article

Properties of a novel plasminogen activator (BM 06.022) produced in Escherichia coli.

Zeitschrift fur Kardiologie - 1 Jan 1990

Martin U, Fischer S, Kohnert U, Lill H, Rudolph R, Sponer G, Stern A, Strein K

Abstract excerpt

Since currently available thrombolytics still show disadvantages, such as administration by infusion, occurrence of intracranial hemorrhage, major hemorrhagic complications, allergic reactions, and high price, a novel tissue plasminogen activator has been developed. BM 06.022 is a t-PA mutant produced in Escherichia coli by DNA technology. It has no oligosaccharide side-chains and comprises the kringle 2- and...

Topics

Animals
Coronary Disease
Coronary Thrombosis
Dogs
Escherichia coli
Fibrin
Fibrinolytic Agents
Humans
Mutation
Rabbits
Recombinant Proteins
Tissue Plasminogen Activator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 2129142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2129142-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Properties of a novel plasminogen activator (BM 06.022) produced in Escherichia coli.PMID 2129142Read ↗

Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator.Semantic proximity Read ↗

In vitro stability of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma.Semantic proximity Read ↗

Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor--and kringle one-domains.Semantic proximity Read ↗

Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022.Semantic proximity Read ↗

Newer thrombolytic agents.Semantic proximity Read ↗

[Biochemical, pharmacologic and clinical properties of new thrombolytic agents].Semantic proximity Read ↗

Tissue-type plasminogen activator: mutants, variants, and adjunctive treatment.Semantic proximity Read ↗

[New types of plasminogen activators].Semantic proximity Read ↗

Comparative study of a mutant tissue-type plasminogen activator, YM866, with a tissue-type plasminogen activator in a canine model of femoral arterial thrombosis.Semantic proximity Read ↗

Recombinant variants of tissue-type plasminogen activator containing amino acid substitutions in the fibronectin finger-like domain and the kringle 1 domain.Semantic proximity Read ↗

Mechanistic studies on Zymogen-Activator and Adhesion Proteins (ZAAPs) as thrombolytic drugs and bacterial virulence factorsSemantic proximity Read ↗

Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin.Semantic proximity Read ↗

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