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Article

Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic-pituitary-thyroid axis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2021

Minakhina Svetlana, De Oliveira Vanessa, Kim Sun Young, Zheng Haiyan, Wondisford Fredric E

Abstract excerpt

Fasting induces profound changes in the hypothalamic-pituitary-thyroid (HPT) axis. After binding thyroid hormone (TH), the TH receptor beta 2 isoform (THRB2) represses Trh and Tsh subunit genes and is the principle negative regulator of the HPT axis. Using mass spectrometry, we identified a major phosphorylation site in the AF-1 domain of THRB2 (serine 101, S101), which is conserved among many members of the...

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Identifiers

PMID: 34544870
DOI: 10.1073/pnas.2107943118
PMCID: PMC8488655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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