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Article

Monitoring oncogenic B-RAF-induced senescence in melanocytes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Tran Sieu L, Rizos Helen

Abstract excerpt

The B-RAF kinase is a downstream effector of the RAS family of proto-oncogenes and is constitutively activated in the majority of human melanomas. The common oncogenic B-RAF(V600E) mutant cooperates with additional genetic lesions to transform immortal murine and human cells. In primary cells, however, B-RAF(V600E) triggers a rapid cell cycle arrest that is phenotypically indistinguishable from cellular...

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Identifiers

PMID: 23296668
DOI: 10.1007/978-1-62703-239-1_21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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