Article
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.
European journal of immunology - 1 Apr 1995
Mustelin T, Williams S, Tailor P, Couture C, Zenner G, Burn P, Ashwell J D, Altman A
Abstract excerpt
Two classes of protein tyrosine kinases (PTK) are utilized by the T cell antigen receptor (TcR)/CD3 complex for initiation of the signaling cascade, the Src-family PTK p56lck and p59fyn, and the Syk-family PTK p70zap and p72syk. In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, presumably by positively regulating Src-family PTK....
Topics
- Cell Line, Transformed
- Humans
- Leukocyte Common Antigens
- Mutation
- Protein Tyrosine Phosphatases
- Protein-Tyrosine Kinases
- Signal Transduction
- T-Lymphocytes