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Article

Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells.

European journal of immunology - 1 Apr 1995

Baldari C T, Di Somma M M, Milia E, Bergman M, Telford J L

Abstract excerpt

Interaction of the CD4 co-receptor with major histocompatibility complex (MHC) class II molecules during antigen presentation results in enhancement of antigen receptor signaling. The synergism between the two receptors is believed to result from the juxtaposition of the CD4-associated tyrosine kinase p56lck with the cytoplasmic domains of CD3 complex components. Here, we report that cross-linking of CD4 on the...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7737294
DOI: 10.1002/eji.1830250409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells.PMID 7737294Read ↗

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.Semantic proximity Read ↗

The role of competing mechanisms on Lck regulation.Semantic proximity Read ↗

The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes.Semantic proximity Read ↗

Genetic and immunochemical evidence for CD4-dependent association of p56lck with the alpha beta T-cell receptor (TCR): regulation of TCR-induced activation.Semantic proximity Read ↗

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).Semantic proximity Read ↗

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.Semantic proximity Read ↗

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.Semantic proximity Read ↗

T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.Semantic proximity Read ↗

Calcium-dependent cyclosporin A-sensitive activation of the interleukin-2 promoter by p56lck.Semantic proximity Read ↗

Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases.Semantic proximity Read ↗

p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.Semantic proximity Read ↗

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.Semantic proximity Read ↗

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