Article
Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells.
European journal of immunology - 1 Apr 1995
Baldari C T, Di Somma M M, Milia E, Bergman M, Telford J L
Abstract excerpt
Interaction of the CD4 co-receptor with major histocompatibility complex (MHC) class II molecules during antigen presentation results in enhancement of antigen receptor signaling. The synergism between the two receptors is believed to result from the juxtaposition of the CD4-associated tyrosine kinase p56lck with the cytoplasmic domains of CD3 complex components. Here, we report that cross-linking of CD4 on the...
Topics
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CSK Tyrosine-Protein Kinase
- Cell Line
- Gene Transfer Techniques
- Humans
- Lymphocyte Activation
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mutation
- Protein-Tyrosine Kinases