Article
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.
The EMBO journal - 7 May 2008
Kulathu Yogesh, Hobeika Elias, Turchinovich Gleb, Reth Michael
Abstract excerpt
Upon B-cell antigen receptor (BCR) activation, the protein tyrosine kinase Syk phosphorylates the adaptor protein SH2 domain-containing leukocyte protein of 65 kDa (SLP-65), thus coupling the BCR to diverse signalling pathways. Here, we report that SLP-65 is not only a downstream target and substrate of Syk but also a direct binding-partner and activator of this kinase. This positive feedback is mediated by the...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Calcium
- Calcium Signaling
- Cell Differentiation
- Cell Line
- Extracellular Signal-Regulated MAP Kinases
- Flow Cytometry
- Green Fluorescent Proteins
- Intracellular Signaling Peptides and Proteins
- Luciferases
- Mice
- Mice, Knockout